Kyleena® IUD Frequently Asked Questions

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Kyleena can cause serious side effects, including:

Ectopic pregnancy and intrauterine pregnancy risks. There are risks if you become pregnant while using Kyleena (see “What if I become pregnant while using Kyleena?”).
Life‐threatening infection. Life‐threatening infection can occur within the first few days after Kyleena is placed. Call your healthcare provider immediately if you develop severe pain or fever shortly after Kyleena is placed.
Pelvic inflammatory disease (PID). Some IUD users get a serious pelvic infection called pelvic inflammatory disease. PID is usually sexually transmitted. You have a higher chance of getting PID if you or your partner has sex with other partners. PID can cause serious problems such as infertility, ectopic pregnancy or pelvic pain that does not go away. PID is usually treated with antibiotics. More serious cases of PID may require surgery, including removal of the uterus (hysterectomy). In rare cases, infections that start as PID can even cause death. Tell your healthcare provider right away if you have any of these signs of PID: long-lasting or heavy bleeding, unusual vaginal discharge, low abdominal (stomach area) pain, painful sex, chills, fever, genital lesions or sores.
Perforation. Kyleena may go into the wall of the uterus (become embedded) or go through the wall of the uterus. This is called perforation. If this occurs, Kyleena may no longer prevent pregnancy. If perforation occurs, Kyleena may move outside the uterus and can cause internal scarring, infection, or damage to other organs, and you may need surgery to have Kyleena removed. Excessive pain or vaginal bleeding during placement of Kyleena, pain or bleeding that gets worse after placement, or not being able to feel the threads may happen with perforation. The risk of perforation is increased if Kyleena is inserted while you are breastfeeding, or if you have recently given birth.
Expulsion. Kyleena may come out by itself. This is called expulsion. Expulsion occurs in about 4 out of 100 women. Excessive pain or vaginal bleeding during placement of Kyleena, pain or bleeding that gets worse after placement, or not being able to feel the threads may happen with expulsion. You may become pregnant if Kyleena comes out. If you think that Kyleena has come out, avoid intercourse or use a non-hormonal back-up birth control (such as condoms or spermicide) and call your healthcare provider. The risk of expulsion is increased with insertion right after delivery or second-trimester abortion.

What are the common side effects of Kyleena?

Common side effects of Kyleena include:

Pain, bleeding, or dizziness during and after placement. If these symptoms do not stop 30 minutes after placement, Kyleena may not have been placed correctly. Your healthcare provider will examine you to see if Kyleena needs to be removed or replaced.
Changes in bleeding. You may have bleeding and spotting between menstrual periods, especially during the first 3 to 6 months. Sometimes the bleeding is heavier than usual at first. However, the bleeding usually becomes lighter than usual and may be irregular. Call your healthcare provider if the bleeding remains heavier than usual or increases after it has been light for a while.
Missed menstrual periods. About 12 out of 100 women stop having periods after 1 year of Kyleena use. If you have any concerns that you may be pregnant while using Kyleena, do a urine pregnancy test and call your healthcare provider. If you do not have a period for 6 weeks during Kyleena use, call your healthcare provider. When Kyleena is removed, your menstrual periods should return.
Cysts on the ovary. About 22 out of 100 women using Kyleena develop a cyst on the ovary. These cysts usually disappear on their own in 2 to 3 months. However, cysts can cause pain and sometimes need surgery.

Other common side effects include:

inflammation or infection of the outer part of your vagina (vulvovaginitis)
abdomen or pelvic pain
headache or migraine
acne or greasy skin
painful periods
sore or painful breasts

In the clinical trails of 1,697 healthy women aged 18-41, the most common adverse reactions (occurring in≥ 5% women) were vulvovaginitis (24%), ovarian cyst (22%), abdominal pain/pelvic pain (21%), headache/migraine (15%), acne/seborrhea (15%), dysmenorrhea/uterine spasm (10%), breast pain/breast discomfort (10%), and increased bleeding (8%).

These are not all of the possible side effects with Kyleena. For more information, please see Full Prescribing Information or ask your healthcare provider.

How will Kyleena change my periods?

Does Kyleena protect against HIV or STIs?

Can I have an MRI with Kyleena in place?

After getting Kyleena

Can I use tampons or menstrual cups with Kyleena?

Will my partner be able to feel Kyleena during sex?

Does Kyleena start working right away, or do I need to use back-up birth control?

Should I check that Kyleena is in place?

How soon should I return to see my healthcare provider after Kyleena has been placed?

Getting pregnant and new moms

What if I change my mind and want to try to get pregnant?

What if I become pregnant while using Kyleena?

Is it safe to breastfeed while using Kyleena?

Cost and insurance coverage

Will my health insurance plan cover Kyleena?

How much does Kyleena cost?

Is there a savings program for Kyleena?

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Hand holding Kyleena® (levonorgestrel-releasing intrauterine system) 19.5 mg IUD

About Kyleena

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What to expect

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INDICATION FOR KYLEENA

Kyleena^® (levonorgestrel-releasing intrauterine system) is a hormone-releasing IUD that prevents pregnancy for up to 5 years.

IMPORTANT SAFETY INFORMATION

If you have a pelvic or genital infection, get infections easily, or have certain cancers, don't use Kyleena. Less than 1% of users get a serious pelvic infection called pelvic inflammatory disease (PID).
If you have persistent pelvic or stomach pain, or excessive bleeding after placement tell your healthcare provider (HCP). If Kyleena comes out, call your HCP and avoid intercourse or use non-hormonal back-up birth control (such as condoms or spermicide). Kyleena may go into or through the wall of the uterus and cause other problems.
Pregnancy while using Kyleena is uncommon but can be life threatening and may result in loss of pregnancy or fertility.
Ovarian cysts may occur but usually disappear.
Bleeding and spotting may increase in the first 3 to 6 months and remain irregular. Periods over time usually become shorter, lighter, or may stop.

Kyleena does not protect against HIV or STIs.

Only you and your HCP can decide if Kyleena is right for you. Kyleena is available by prescription only.

For important risk and use information about Kyleena, please see Full Prescribing Information.

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